2019 Jan;39:520-530. doi: 10.1016/j.ebiom.2018.11.038. Close this message to accept cookies or find out how to manage your cookie settings. Cuello, Mauricio A. The periodical return of the symptoms after a shorter or longer period of quiescence. Rapture was self-transcending, which led … This active and highly regulated process is called myometrial quiescence. At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. Context sentences for "quiescence" in Polish These sentences come from external sources and may not be accurate. Render date: 2021-01-22T15:18:36.920Z quiescence . For clusters related to quiescence and term activation, a change of more than 20% was required for the midgestation (14.5 days) and term (18.5 days) time points, respectively, versus non-pregnant controls. Synonym Discussion of quiescent. and 2013. Feature Flags: { Delpiano, Ana M. 2016. Sobrevia, Luis A. Jofré, Nicolás M. Cuello, Mauricio A. It requires not only the near absence of myometrial contractions, but also its refractoriness to contractile agents. Get access to the full version of this content by using one of the access options below. The causes of preterm labor are not well understood, so progesterone action on the myometrium can provide clues about the processes that … Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. Carvajal, Jorge A. Weiner, Carl P. "shouldUseShareProductTool": true, Ferrer, Fernando Andrés In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. If you should have access and can't see this content please. 2017. Hostname: page-component-76cb886bbf-pdn9z bab.la is not responsible for their content. Vargas, Paula A. "shouldUseShareProductTool": true, and translation and definition "quiescence", English-Greek Dictionary online. The first phase is quiescence and represents that time in utero before labor begins when uterine activity is suppressed by the action of progesterone, prostacyclin, relaxin, nitric oxide, Cells may exit the cell cycle at G 1 and enter a nonproliferative phase called G 0 or quiescence. The highest rates of preterm birth (≥15% of all live births) occur in sub-Saharan Africa, Pakistan and Indonesia. Arias-Montaño, José-Antonio This data will be updated every 24 hours. * Views captured on Cambridge Core between September 2016 - 24th January 2021. Learn more. In contrast, UC frequency remained elevated (at 60% end-follicular phase values) until 4 days after hCG and declined thereafter (6 days after hCG). We use cookies to distinguish you from other users and to provide you with a better experience on our websites. 2009. Quiescent definition is - marked by inactivity or repose : tranquilly at rest. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. for this article. Delpiano, Ana M. } Effects of progesterone treatment on expression of genes involved in uterine quiescence. Santiago, Chile. A. Oxytocin inhibits contraction of uterine smooth muscle What explains the quiescence of uterine smooth muscle during gestation? Soria-Jasso, Luis Delpiano, Ana M. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. Carvajal, Jorge A. Cuello, Mauricio A. }, Uterine quiescence: the role of cyclic AMP, Nuffield Department of Obstetrics and Gynaecology, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. }. Address for correspondence: Jorge A Carvajal, Marcoleta 391, Centro de Investigaciones Médicas, Pontificia Universidad Católica de Chile, Santiago, Chile. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. Poblete, Jose A. Using the mouse as our model system, we examined, by Western blot analysis, levels of active caspase 3 and its association with the degradation of uterine contractile proteins during pregnancy. Experimental Physiology (2001) 86.2, 265-272. "newCiteModal": false In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence. "lang": "en" Close this message to accept cookies or find out how to manage your cookie settings. English In human pre-term labour, atosiban at the recommended dosage antagonises uterine contractions and induces uterine quiescence . Carvajal, Jorge A. Published online by Cambridge University Press:  2006. In this study, we uncovered a previously undescribed regulatory pathway whereby … Furthermore, by means of immunoblotting and immunocytochemistry, we have demonstrated the expression of these isoforms as membrane-associated AC proteins, and identified changes in individual AC isoform expression during gestation. and The appropriate timing of the onset of labor is critical to a successful pregnancy, with potentially devastating consequences resulting to both the mother and child with the onset of preterm labor. Published online by Cambridge University Press:  In this situation, measurement of cervical length during quiescence and during a uterine contraction is useful for differentiating a normal latent phase from dysfunctional active labor. Maximal uterine quiescence was reached as early as 4 days after the LH surge (P<.05). Did You Know? "openAccess": "0", Found 10 sentences matching phrase "quiescence".Found in 3 ms. Feature Flags: { uterine definition: 1. relating to the uterus: 2. relating to the uterus: 3. of or relating to the uterus: . Author information: (1)Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555, USA. Whether a decrease in plasma progesterone is the essential prerequisite for the initiation of parturition or whether other factors also maintain uterine quiescence until delivery is not known. uterine quiescence and days to delivery. "isLogged": "0", We have verified the presence of mRNA encoding adenylyl cyclase (AC) isoforms I, II, III, V, VI, VII, VIII and IX in both non-pregnant and pregnant human myometrium, and in isolated myometrial cells maintained in cell culture. "isLogged": "0", Fernández-Martínez, Eduardo In the menstrual cycle, a prompt decrease in UC frequency was observed. The safety and analysis populations were defined as all … Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy EBioMedicine. This data will be updated every 24 hours. As a result, forceful uterine contractions do not occur until the ninth month of pregnancy. Additional filters were used downstream of clustering for genes related to uterine quiescence and term activation. The At the molecular level, an integrated uterine endoplasmic reticulum stress-unfolded protein response (UPR-ERSR) regulates both caspase-3 (CASP3) and caspase-7 (CASP7), preserving myometrial quiescence throughout gestation. 31 July 2001. "metricsAbstractViews": false, Inactive, resting, silent Medtalk A period during which an infection is present but not active in a host Examples TB; chickenpox and recrudescence as herpes zoster–shingles. } Total loading time: 1.54 relative uterine quiescence during continuing pregnancy to the initiation of uterine contractions at the onset of labour. At present, the exact factors initiating human parturition remain unknown, and labour may occur due to a loss of uterine quiescence, an increase in uterine contractility, or a combination of both. Epub 2018 Nov 28. This active and highly regulated process is called myometrial quiescence. View all Google Scholar citations Adequate uterine contractility is involved in the transport of the semen and gametes and in successful embryo implantation, whereas inadequate uterine contractility may lead to ectopic pregnancies, miscarriages, retrograde bleeding and endometriosis (Leyendecker et al., 2004; Bulletti and de Ziegler, 2005; Kissler et al., 2005). Hostname: page-component-76cb886bbf-kdwz2 Poblete, José A. labor are unique. Mayén-García, Cynthia Ortiz, Mario View all Google Scholar citations In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. These include the possibility of electrophysiological changes in myometrial cells. The planned sample size (n=64) provided at least 86% power to detect a 40% absolute difference, or RR of 2.6, in the proportion of women achieving uterine quiescence. Vidal, Rossana J. Delpiano, Ana María Ponce-Monter, Héctor These findings illustrate the diversity of potential cAMP generating pathways in human myometrium, and the complexity of the signal transduction systems underlying uterine quiescence. translation and definition "quiescence", English-Greek Dictionary online. "isUnsiloEnabled": true, Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and have a negative impact on PR function. In fertile women, directed unilateral transport of immotile sperm-like material through the genital tract to the side bearing the dominant follicle can be assessed using hysterosalping… The safety and analysis populations were defined as all … and A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. "hasAccess": "0", Query parameters: { Get access to the full version of this content by using one of the access options below. and "figures": false, Cuello, Mauricio A. : The early Cretaceous is characterized by relative quiescence and thermal subsidence following late Jurassic rifting. It is accepted that whilst hormones such as oxytocin, vasopressin and prostaglandin F2α induce myometrial contractions, essentially via an elevation of intracellular calcium, other ligands, such as β-adrenoceptor agonists, calcitonin gene-related peptide, and prostaglandin E2, promote uterine quiescence via their ability to increase intracellular cyclic AMP levels. Throughout most of pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) transcriptional activity, whereas spontaneous labor is initiated/facilitated by a concerted series of biochemical events that activate inflammatory pathways and have a … * Views captured on Cambridge Core between September 2016 - 22nd January 2021. During pregnancy, uterine quiescence is maintained by increased progesterone receptor (PR) activity, but labor is facilitated by a series of events that impair PR function. We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Bethune was a man of peace, one who wanted stability and who in the interests … https://doi.org/10.1017/S0965539503001098. 16 October 2003. "lang": "en" "hasAccess": "0", The uterus (from Latin "uterus", plural uteri) or womb (/ w uː m /) is a major female hormone-responsive secondary sex organ of the reproductive system in humans and most other mammals.In the human, the lower end of the uterus, the cervix, opens into the vagina, while the upper end, the fundus, is connected to the fallopian tubes.It is within the uterus that the fetus develops during gestation. The regulation of uterine activity during pregnancy can be divided into four distinct physiologic phases : Phase 0: inhibitors active – Throughout most of pregnancy the uterus is maintained in a state of functional quiescence through the action of various putative inhibitors including, but not limited to: A successful pregnancy requires near complete relaxation of the uterus for more than ninety-five percent of gestation, overcoming the inherent tendency of the myometrium to contract with stretch. Casanello, Paola C. : The next four decades saw periods of resurgence and quiescence in Soviet anti-Semitism. Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland Baltimore, School of Medicine, Baltimore, Maryland. What explains the quiescence of uterine smooth muscle during gestation? MECHANISMS UNDERLYING MYOMETRIAL QUIESCENCE DURING... Department of Obstetrics and Gynecology; Maternal-Fetal Research Laboratory. PARTURITION is defined as the process of bringing forth of young which comprises of multiple transformations in both uterine and cervical functions There are four phases : Quiescence Carvajal, Jorge A. Carvajal, Jorge Andrés "newCiteModal": false An important action of progesterone during pregnancy is to maintain the uterus in a quiescent state and thereby prevent preterm labor. 2013. The four phases of labor from quiescence to involution are outlined in Figure 13-1. In this study, we tested the central hypothesis that progesterone maintains uterine quiescence through regulation of active uterine caspase 3. Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views. 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