This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. Brimonidine Tartrate And Timolol Maleate Ophthalmic Solution 0.15%... ₹ 70/Bottle Get Quote Allopathic Brimonidine And Timolol Eye Drops, Packaging Type: Bottle For Clinical Management: Dose reduction of suvorexant and/or any other CNS depressant may be necessary. Initiate buprenorphine at lower doses in patients already receiving CNS depressants. Combigan eye drops are used to lower raised pressure in the eye and to treat glaucoma.. Glaucoma is a condition in which the pressure of the fluid in the eye may be high. Specifically, beta-blockers may reduce the effectiveness of beta-agonists that may be required to treat systemic reactions to white birch allergen extract. Structures of Brimonidine Tartrate and Timolol Maleate respectively Eye drops (Combigan eye drop) containing Timolol Maleate equivalent to 0.5% of Timolol and 0.2% of Brimonidine are instilled twice daily to reduce raised intra-ocular pressure in open-angle glaucoma and ocular hypertension. Monitor therapy, Nonsteroidal Anti-Inflammatory Agents (Topical): May diminish the therapeutic effect of Beta-Blockers. UV-1800 double beam UV-VIS spectrophotometer (Shimadzu) with a pair of 10mm path length matched quartz cells is used for the study. Consider therapy modification, Blonanserin: CNS Depressants may enhance the CNS depressant effect of Blonanserin. Recommended dosage in adults (including the elderly) The recommended dose is one drop of Brimonidine Tartrate/Timolol in the affected eye(s) twice daily, approximately 12 hours apart. Treatment of anaphylaxis (eg, epinephrine) in patients taking beta-blockers may be ineffective or promote undesirable effects. Consult your pharmacist or local waste disposal company.Information last revised August 2020. Management: Reduce the Intermezzo brand sublingual zolpidem adult dose to 1.75 mg for men who are also receiving other CNS depressants. Eye drops. Temporary blurred vision, temporary burning/stinging/itching/redness of the eye, watery eyes, dry eyes, dry mouth, feeling as if something is in the eye, headache, dizziness, or drowsiness may occur. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. Monitor therapy, White Birch Allergen Extract: Beta-Blockers may enhance the adverse/toxic effect of White Birch Allergen Extract. Combigan eye drops contain the active ingredients brimonidine (0.2%), an alpha-2 adrenergic agonist and timolol (0.5%). COMBIGAN® (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% is an alpha-adrenergic receptor agonist with a beta-adrenergic receptor inhibitor indicated for the reduction of... 2 DOSAGE AND ADMINISTRATION The recommended dose is one drop … Avoid combination, Zolpidem: CNS Depressants may enhance the CNS depressant effect of Zolpidem. Monitor therapy, Propafenone: May increase the serum concentration of Beta-Blockers. • Thyroid disease: May mask signs of hyperthyroidism (eg, tachycardia). Monitor therapy, Lisuride: May enhance the CNS depressant effect of CNS Depressants. • Angle-closure glaucoma: Appropriate use: Not for use alone to treat acute angle-closure glaucoma (has no effect on papillary constriction). To avoid contamination of the eye or eye drops do not allow the dropper tip to come into contact with any surface. Timolol: Blocks both beta-1 and beta-2 adrenergic receptors, reduces intraocular pressure by reducing aqueous humor production or possibly outflow; reduces blood pressure by blocking … • Cardiovascular disease: Use with caution in patients with compensated heart failure or coronary insufficiency. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Monitor therapy, Alcohol (Ethyl): CNS Depressants may enhance the CNS depressant effect of Alcohol (Ethyl). If you notice other effects not listed above, contact your doctor or pharmacist. How long have you been taking Brimonidine-Timolol Drops? The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. • Anaphylactic reactions: Use caution with history of severe anaphylaxis to a variety of allergens; patients taking beta-blockers may become more sensitive to repeated challenges. Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Monitor therapy, Methotrimeprazine: CNS Depressants may enhance the CNS depressant effect of Methotrimeprazine. Brimocom eye drops contain the active ingredients brimonidine (0.2%), an alpha-2 adrenergic agonist and timolol (0.5%), a non-selective beta-adrenergic receptor blocker that work together to lower intraocular pressure (IOP) and reduce risk of glaucoma. It belongs to a class of drugs known as alpha agonists. How to use Brimonidine TARTRATE Drops To apply eye drops, wash your hands first. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Monitor therapy, Bromopride: May enhance the CNS depressant effect of CNS Depressants. Management: Consider avoiding concurrent use. Tilt your head back, look up, and pull down the lower eyelid to make a pouch. Brimonidine and timolol ophthalmic (eye) drops are used to treat increased pressure in the eye caused by glaucoma or a condition called hypertension of the eye. Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, heart disease, blood vessel disease (e.g., thromboangiitis obliterans, Raynaud's phenomenon), blood circulation disorders (cerebral/coronary insufficiency), dizziness after standing (orthostatic hypotension), diabetes, depression, overactive thyroid (hyperthyroidism), muscle weakness disorders (e.g., myasthenia gravis), severe allergies. This medicine may be harmful if swallowed. Topical application of eye drops is (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% combigan.com For Providers Keep using this medication even if you feel well. Monitor therapy, Mianserin: May diminish the therapeutic effect of Alpha2-Agonists (Ophthalmic). The risk associated with ophthalmic products is probably less than systemic products. These agents should only be combined if alternative treatment options are inadequate. Monitor therapy, CYP2D6 Inhibitors (Strong): May increase the serum concentration of Timolol (Ophthalmic). Avoid combination, Peginterferon Alfa-2b: May decrease the serum concentration of CYP2D6 Substrates (High risk with Inhibitors). Avoid combination, Oxybate Salt Products: CNS Depressants may enhance the CNS depressant effect of Oxybate Salt Products. This medication is not recommended for use in children less than 2 years old due to an increased risk of serious side effects. Note: In the Canadian labeling, use in children (at any age) is not recommended. Monitor therapy, Rifamycin Derivatives: May decrease the serum concentration of Beta-Blockers. If concomitant use cannot be avoided, monitor patients closely for evidence of excessive peripheral vasoconstriction. What should I know regarding pregnancy, nursing and administering Brimonidine-Timolol Drops to children or the elderly? Also see individual agents. Management: Avoid the concomitant use of fingolimod and beta-blockers if possible. This likely applies only to those agents that are metabolized by CYP2D6. Beta-Blockers may enhance the rebound hypertensive effect of Alpha2-Agonists. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. Consider therapy modification, Lidocaine (Systemic): Beta-Blockers may increase the serum concentration of Lidocaine (Systemic). For the properties of the components please consider the following; TIMOLOL MALEATE; BRIMONIDINE TARTRATE… Management: Closely monitor heart rate during treatment with a beta blocker and clonidine. Monitor therapy, Brexanolone: CNS Depressants may enhance the CNS depressant effect of Brexanolone. 2017 Jun;34(6):1438-1448. doi: 10.1007/s12325-017-0552-5. Most people with glaucoma or high pressure in the eyes do not feel sick. Monitor therapy, Nonsteroidal Anti-Inflammatory Agents: May diminish the antihypertensive effect of Beta-Blockers. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Before having surgery, tell your doctor or dentist that you are using this medication. This medication passes into breast milk, but is unlikely to harm a nursing infant. Repeat these steps for your other eye if so directed. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Consult your doctor before breast-feeding. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Patients may need to take more than one eye drop product pursuant to multiple dosing regimens, as directed by his or her prescriber, in order for the active ingredients to remain effective throughout the day. Instill 1 drop in the affected eye (s) twice daily approximately 12 hours apart. Of particular concern are the potential for cardiac conduction abnormalities and bronchoconstriction. Does Brimonidine-Timolol Drops interact with other medications? Monitor therapy, Lacosamide: Bradycardia-Causing Agents may enhance the AV-blocking effect of Lacosamide. Monitor therapy, Dronedarone: May enhance the bradycardic effect of Beta-Blockers. Timolol is thought to work by decreasing the amount of fluid formed in the eye. Brimonidine/timolol (INNs, trade name Combigan) are combination eye drops indicated for the treatment of glaucoma.It is a combination of brimonidine (an α 2 adrenergic agonist) and timolol (a β adrenergic blocker), in concentrations of 0.2% and 0.5% respectively.Both substances work by decreasing the synthesis of aqueous humor.. Combigan is marketed and sold by Allergan. Consider therapy modification, Droperidol: May enhance the CNS depressant effect of CNS Depressants. Monitor therapy, CNS Depressants: May enhance the adverse/toxic effect of other CNS Depressants. Before using this product, tell your doctor or pharmacist if you are allergic to brimonidine or timolol; or to apraclonidine; or if you have any other allergies. Timolol … Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. 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