To better understand the genetic landscape, an integrated … A high level of Epstein-Barr virus (EBV) antibodies in the blood after treatment indicates a poorer prognosis. The age of the patient The health status of the patient Family history Consumption of salted fish in the diet Tobacco smoking The size of the tumor (2) The type of nasopharyngeal cancer (1) The stage of cancer whether it … Keywords: Nasopharyngeal carcinoma, Circulating tumor cells, Epstein-Barr virus DNA, Prognosis, Cut-off point Introduction Circulating tumor cells (CTCs) count using the CellSearch system (Janssen Diagnostics, … Nasopharyngeal carcinoma (NPC) is a cancer rising from nasopharynx epithelium [].Unlike other head and neck cancers, NPC has remarkably skewed ethnic and geographic distributions [].In certain regions such as southeast Asia and northern Africa, NPC has relatively higher prevalence than elsewhere, with viral infection, genomic landscape and some environment factors … Nasopharyngeal carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat. We searched PubMed, Web of Science, and the Cochrane library for prospective and retrospective studies. Results: Nasopharyngeal carcinoma is diagnosed by biopsy of the tumor, which is often performed in clinic with a use of a small endoscope. Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein-Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma. Spread to lymph nodes Nasopharyngeal cancer that has spread to the lymph nodes in the neck (cervical lymph nodes) has a poorer prognosis. If nasopharyngeal cancer has spread to the lymph nodes in the lower areas of the neck, the prognosis is also poorer. Radiation therapy to the tumor and lymph nodes in the neck. Nasopharyngeal carcinoma which is also known as nasopharyngeal cancer is a type of cancer on the neck and head that rarely occurs, but it could affect both males and females. Nasopharyngeal cancer is a rare type of head and neck cancer.It starts in the upper part of your throat, behind the nose. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated tumor occurring in southeastern Asia. Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer that is endemic to the southern region of China. Heat shock protein 90α (HSP90α) is an important member of the heat shock protein … If nasopharyngeal cancer has spread to the lymph nodes in the lower areas of the neck, the prognosis is also poorer. 2013; Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015 n.d.), the proportions of CTCs in different age groups and genders were also analyzed here (Additional file 4: Table S3 and Additional file 5: Table S4). In the United States and other countries where nasopharyngeal cancer (NPC) is fairly rare, doctors do not recommend routine screening for this cancer. Discover how 16 factors affect your cancer risk and how you can take action with our interactive tool – It’s My Life! Diagnosis. Nasopharyngeal cancer is a type of head and neck cancer that occurs when cells in the nasopharynx, the upper part of the throat behind the nose and near the base of the skull, grow out of control.. Hazard ratios (HRs) and confidence intervals (CIs) were extracted from the studies or calculated and pooled to assess the association between EBV DNA levels pre-treatment (pre-DNA), mid-treatment (mid-DNA), and post-treatment (post-DNA) on clinical outcomes. Nasopharyngeal carcinoma. Background: Nasopharyngeal carcinoma (NPC) is an entity belonging to up-per aerodigestive tract Cancers. NPC is more widespread in Southern China and South East Asia. If we are not able to reach you by phone, we will leave a voicemail message. Nasopharyngeal carcinoma is the most common malignant tumor of the head and neck in Southeast Asia and originates from the epithelium of the nasopharynx. Experimental Design: Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. Nasopharyngeal Carcinoma … EBV infection is closely related to the development and progression of nasopharyngeal carcinoma, but it is still to be clarified how EBV infection promotes tumorigenesis. Up till now there is limited prognostic data on the role of TILs in NPC, so we assessed the prognostic role of TILs in Epstein-Barr-virus (EBV) positive and © 2021 Canadian Cancer Society All rights reserved. Positron emission tomography (PET) 4. The lower the stage, the better the prognosis. Purpose: To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). chemotherapy first, … Prognostic value of gross tumor regression and plasma Epstein Barr Virus DNA levels at the end of intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma. Please enable it to take advantage of the complete set of features! A predictive factor influences how a cancer will respond to a certain treatment. Scientists are still researching how EBV leads to nasopharyngeal cancer, but it may be related to genetic material (DNA) from the virus affecting the DNA in the cells of the nasopharynx. Keywords: The significance of SOX2 in nasopharyngeal carcinoma (NPC), a tumor associated with Epstein-Barr virus (EBV), remains unclear. Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated cancer characterized by a poor prognosis and a high level of lymphocyte infiltrate. Would you like email updates of new search results? Background. In our country, it is the leading cause of head and neck cancers. Registered charity: 118829803 RR 0001, International Cancer Information Service Group. A prognostic factor is an aspect of the cancer or a characteristic of the person (such as whether they smoke) that the doctor will consider when making a prognosis. 2014 ). 56 and 58 year old men with glandular differentiation in EBV positive nasopharyngeal carcinoma (Arch Pathol Lab Med 2000;124:1369) Treatment Radiation therapy is the mainstay of treatment for all histologic types of nasopharyngeal carcinoma ( NCCN: NCCN Guidelines - Head and Neck Cancers [Accessed 14 October 2020] ) 1,2 More than 70% of new NPC cases were reported in East and Southeast Asia. 2019 Mar;132:223-229. doi: 10.1016/j.radonc.2018.10.010. 2020 Sep 20;12:1758835920951346. doi: 10.1177/1758835920951346. We investigated the prognosis of NPC patients with residual cervical lymphadenopathy and assessed the diagnostic and prognostic values of Epstein-Barr virus (EBV) DNA in these patients. Cancer Lett 374(1):22–30 1 INTRODUCTION. Nasopharyngeal carcinoma (NPC) is a unique head and neck cancer with high prevalence rates in southern China, Southeast Asia, North Africa, the Middle East and Alaska.1 Currently, tumor, node and metastasis (TNM) staging is the main tool in determining treatment strategy and assessment of prognosis. Epub 2018 Oct 23. The viral influence is associated with infection with Epstein-Barr virus(EBV). -, Chua DTT, Sham JST, Kwong DLW, Au GKH (2003) Treatment outcome after radiotherapy alone for patients with Stage I–II nasopharyngeal carcinoma. Males are more commonly affected, with a male to female ratio of 3:1. Nasopharyngeal carcinoma (NPC) arises from the lining of the nasopharynx, the narrow tubular passage behind the nasal cavity. Only a doctor familiar with your medical history, the type and stage and other features of the cancer, the treatments chosen and the response to treatment can put all of this information together with survival statistics to arrive at a prognosis. Prognosis and survival depend on many factors. Late presentation is a common issue and early detection could be the key to reduce the disease burden. Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia, where a peak incidence of 50 cases per 100 000 has been reported (Wee et al, 2010). Epidemiology. Nasopharyngeal carcinoma accounts for ~70% of all primary malignancies of the nasopharynx, and although rare in western populations, it is one of the most common malignancies encountered in Asia, especially China 1,3-5.It is commonly diagnosed between 40 and 60 years. eCollection 2020. Presented in partnership with Desjardins. 1 World Health Organization type III is the most common pathologic type of NPC in high‐prevalence areas and is believed to be associated with Epstein‐Barr virus (EBV) infection. The pathogenic role of Epstein-Barr virus (EBV) for the initiation and progression of nasopharyngeal carcinoma (NPC) has been highly investigated since EBV-DNA was identified in an NPC tumor specimen . The stage is the most important prognostic factor for nasopharyngeal cancer. Liu SL, Sun XS, Li XY, Tang LQ, Chen QY, Lin HX, Liang YJ, Yan JJ, Lin C, Guo SS, Liu LT, Li Y, Xie HJ, Tang QN, Liang H, Guo L, Mai HQ. New evidence indicates that exosomes may play as an important mediator in this EBV-tumorigenic progress. J Natl Cancer Inst 94(21):1614–1619 worse prognosis in solid tumors. The EBV DNA levels have a significant prognostic impact in patients with NPC. To compare the NPC-related diagnostic value of EBV RecombLine test (Mikrogen, Germany) with a standardized immunoblot assay [Fachiroh J, Schouten T, Hariwiyanto B, Paramita DK, Harijadi A, Haryana SM, et al. Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. X-ray Once your doctor has determi… Nasopharyngeal carcinoma (NPC) is a tumor arising from the epithelial cells that cover the surface and line the nasopharynx. Molecular diversity of Epstein–Barr virus IgG and IgA antibody responses in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese, and European subjects. 1 There were approximately 42,100 new cases of NPC in China in 2013, accounting for 1.14% of all new cancer cases in China. 2017 Dec 29;36(1):98. doi: 10.1186/s40880-017-0264-x. 95% of all people in the U.S. are exposed to this virus by the time they are 30–40 years old. Shi Z, Jiang W, Chen X, Xu M, Wang X, Zha D. Ther Adv Med Oncol. Nasopharyngeal carcinoma (NPC) is an uncommon cancer of the back of the head and throat, which has a distinctive ethnic and geographic distribution. For example, if the 5-year relative survival rate for a specific stage of nasopharyngeal cancer is If you have nasopharyngeal cancer, you may have questions about your prognosis. Yao JJ, Zhou GQ, Wang YQ, Wang SY, Zhang WJ, Jin YN, Zhang F, Li L, Liu LZ, Cheng ZB, Ma J, Qi ZY, Sun Y. Chin J Cancer. Or write us. NPC differs significantly from other cancers of the head and neck in its occurrence, causes, clinical behavior, and treatment. In view of the factors that affecting the prognosis of NPC also include age and gender (Xiao et al. Our previous study … NLM We performed a meta-analysis of studies including data from 8128 patients to evaluate the prognostic value of EBV DNA in NPC patients. We will reply by email or phone if you leave us your details. 1 INTRODUCTION. This site needs JavaScript to work properly. Methods: Sensitivity of plasma EBV DNA, an established NPC biomarker, for Stage I NPC is controversial. Serum amyloid A (SAA) has been associated with the development and prognosis of cancer. That's probably because the nasopharynx isn't eas… Testing of the tumor for EBV is also recommended. Nasopharyngeal carcinoma (NPC) ... they reported that SAA wasn't an independent prognostic factors and they did not assess the use of integrated SAA and EBV DNA (S‐D grade) in the prognosis of NPC. The diagnostic and prognostic values of plasma Epstein-Barr virus DNA for residual cervical lymphadenopathy in nasopharyngeal carcinoma patients: a retrospective study. The patient with nasopharyngeal carcinoma (NPC) frequently is initially seen with regional node dissemination. Clinical presentation, diagnosis, treatment, and prognosis ... Clearly, the anti-EBV serologic findings separate the WHO type 1 tumors from the WHO type 2 and 3 tumors. Because EBV miRNAs could be delivered by exosomes, out of RNases, they are more stable in tissues and serum compared to circulating tumor DNAs. Imaging tests may include: 1. Unfortunately most nasopharyngeal cancers are found at a later stage, when the cancer has spread to lymph nodes or distant organs. Life expectancy for nasopharyngeal cancer is often expressed in 5-year survival rates, that is, how many people will be alive 5 years after diagnosis. Plasma levels of Epstein-Barr virus (EBV) DNA have been employed to predict survival outcomes of patients with nasopharyngeal carcinoma (NPC). Medicine (Baltimore). Keywords: nasopharyngeal carcinoma; EBV; oncogenesis; infection; signaling pathway 1. This makes it likely that the nasopharyngeal cancer has also spread to distant organs. EBV infections are very common — you’ve probably already contracted the virus without even knowing it. EBV detection of nonkeratinizing nasopharyngeal carcinoma is linked to EBV in 100% of cases, regardless of the ethnicity of the patients. ... 86 700 new cases of NPC and 50 800 deaths in 2012. Endemic to China, the malignancy shows a variable rate of occurrence ranging from high incidence in the Southern part of China to a low rate in the White population and Northern China with the incidence ranging from 15 to 50 per 100000. In conclusion, miR-3182 and EBV-miR-BART8-3p are highly expressed in nasopharyngeal carcinoma and correlated with distant metastasis and poor prognosis. 2019 Mar 29;39(1):14. doi: 10.1186/s40880-019-0357-9. Introduction. Naso- and Oropharyngeal Carcinoma. Experimental Design: Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. Very rarely does Epstein-Barr virus lead to cancer, which suggest… The combined detection of CTCs and EBV-DNA could better predict the prognosis of NPC compared with the single detection of EBV-DNA. Most nasopharyngeal cancers are nasopharyngeal carcinoma.There are three types of nasopharyngeal cancer: . Radiat Oncol (Lond, Engl) 10:89 Stage II Nasopharyngeal Cancer. Tumours with negative surgical margins have a better prognosis. : a systematic review and meta-analysis of 7836 cases. Background. COVID-19 is an emerging, rapidly evolving situation. Multiple risk factors, including host genetics, environmental factor, and EBV infection, have been linked to the development of NPC, particularly in the familial clustering cases. Non-keratinizing squamous cell carcinoma has a better prognosis than other types of nasopharyngeal cancer. As therapeutic modalities for nasopharyngeal carcinoma (NPC) are limited, immunotherapy could be a potential alternative. Epstein-Barr virus (EBV) is associated with multiple types of human cancer, including lymphoid and epithelial cancers. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. | Nasopharyngeal carcinoma (NPC) differs from malignant tumors arising from other head and neck mucosal sites in epidemiology, pathological types, and treatment [].NPC has a distinct ethnic and geographical distribution in Guangdong, South China, where environmental factors, genetic predisposition, and Epstein-Barr virus (EBV) infection play important roles in its pathogenesis. Nasopharyngeal carcinoma (NPC) is an uncommon cancer of the back of the head and throat, which has a distinctive ethnic and geographic distribution. The effect of post-treatment EBV DNA level dominated that of pre-DNA and mid-DNA levels. Liang SB, Zhang N, Chen DM, Yang XL, Chen BH, Zhao H, Lu RL, Chen Y, Fu LW. Keywords: Nasopharyngeal carcinoma, Circulating tumor cells, Epstein-Barr virus DNA, Prognosis, Cut-off point Introduction Circulating tumor cells (CTCs) count using the CellSearch system (Janssen Diagnostics, Raritan, NJ, USA) has been proved to have good prognostic value for metastatic breast cancer (Bidard et al. NPC is more widespread in Southern China and South East Asia. Nasopharyngeal carcinoma (NPC) is a heterogeneous epithelial tumour highly prevalent in East and Southeast Asia [].It is characterised by Epstein–Barr virus (EBV) infection and heavy lymphocyte infiltration [].These special features of the NPC tumour microenvironment (TME) indicate the potential benefits of immune checkpoint inhibitors (ICIs). Computerized tomography (CT) 2. (Screening is testing for cancer in people without any symptoms.) Prognostic and predictive factors are often discussed together. -, He Y, Zhou Q, Shen L, Zhao Y, Lei M, Wei R et al (2015) A retrospective study of the prognostic value of MRI-derived residual tumors at the end of intensity-modulated radiotherapy in 358 patients with locally-advanced nasopharyngeal carcinoma. | Bookmarks (0) Head and Neck. EBV-miR-BART8-3p is a useful biomarker predicting distant metastasis and poor survival of NPC. HHS A total of 22 studies with 8128 patients was included for analysis. EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein–Barr virus (EBV)‐associated and has the highest incidence and mortality rates mostly in Southeast Asia. Cancer Commun (Lond). doi: 10.1097/MD.0000000000005130. The presence of monoclonal EBV episomes in NPC tumor cells indicates that virus infection precedes the clonal expansion of the malignant cell population. Genetic studies indicate that mutations in chromatin-modifying enzymes are the most frequent genetic alterations in NPC. However, due to its low positive predictive rate, it is ess … Purpose: To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). Knowing the structures and how the nasopharynx work will help an individual understand nasopharyngeal carcinoma. It occurs much more frequently in other parts of the world — specifically Southeast Asia.Nasopharyngeal carcinoma is difficult to detect early. Epstein-Barr virus DNA level as a novel prognostic factor in nasopharyngeal carcinoma: A meta-analysis. Zhang J, Shu C, Song Y, Li Q, Huang J, Ma X. Pre-DNA levels predicted overall survival, progression-free survival, distant metastasis-free survival, and local-regional failure survival with HRs (95% CIs) of 2.70 (2.06, 3.54), 2.70 (2.12, 3.44), 3.49 (2.35, 5.17), and 2.00 (1.45, 2.76), respectively, and the corresponding HRs for post-DNA levels were 4.86 (3.30, 7.17), 6.29 (3.41, 11.60), 5.68 (2.71,11.93), respectively. Radiother Oncol. Smaller tumours (less than 2 cm) have a better prognosis than larger tumours. The ISH for EBV-encoded early RNA (EBER) is the most effective … A2018425/Guangdong Medical Research Foundation, FS0AA-KJ218-1301-0006/the Science and Technology Innovation Project from Foshan, Guangdong, Tang LL, Chen WQ, Xue WQ, He YQ, Zheng RS, Zeng YX et al (2016) Global trends in incidence and mortality of nasopharyngeal carcinoma. The margin is the area of healthy tissue around a tumour that is removed along with the tumour during surgery. A relative survival rate compares people with the same type and stage of cancer to people in the overall population. Conclusion: -, Chua MLK, Wee JTS, Hui EP, Chan ATC (2016) Nasopharyngeal carcinoma. Introduction Nasopharyngeal carcinoma (NPC) is a malignant cancer, which is located behind the nose at the very upper part of the throat. A prognosis is the doctor’s best estimate of how cancer will affect someone and how it will respond to treatment. Imaging techniques (MRI and/or CT scan) may also help determine the extent of the tumor. Nasopharyngeal carcinoma (NPC), or nasopharynx cancer, is the most common cancer originating in the nasopharynx, most commonly in the postero-lateral nasopharynx or pharyngeal recess (fossa of Rosenmüller), accounting for 50% of cases.NPC occurs in children and adults. Prognostic and clinicopathological value of Ki-67 expression in patients with nasopharyngeal carcinoma: a meta-analysis. They both play a part in deciding on a treatment plan and a prognosis. Epstein-Barr virus (EBV) is a member of the herpesvirus family that can infect humans. Thus, it is particularly important to identify sensitive and specific biomarkers for early diagnosis and prognosis . This area is called the nasopharynx. Here, we used H3K27ac chromatin immune precipitation … Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. These other health issues are called comorbidities. Nasopharyngeal carcinoma (NPC) is originated from the epithelial cells of nasopharynx, Epstein-Barr virus (EBV)-associated and has the highest incidence and mortality rates in Southeast Asia. Nasopharyngeal carcinoma frequently spreads (metastasizes) beyond the nasopharynx. Medicine (Baltimore). doi: 10.1097/MD.0000000000000845. Nasopharyngeal carcinoma (NPC), previously known as lymphoepithelioma, is a malignancy arising from the epithelium of the nasopharynx. Cancer 98(1):74–80 Currently, the diagnosis and treatment of nasopharyngeal carcinoma (NPC) patients with residual cervical lymphadenopathy following radical radiotherapy with or without chemotherapy are challenging. It is endemic to southern China and Asia and is etiologically associated with the Epstein–Barr virus (EBV) Ma, Hui, & Chan, 2017). -. link. If there are cancer cells in the margin, it is called a positive surgical margin. NPC is caused by a combination of factors: viral, environmental influences, and heredity. 2020 Oct 12;20:498. doi: 10.1186/s12935-020-01587-z. The following are prognostic and predictive factors for nasopharyngeal cancer. 1, 2 In a 2018 global report, morbidity due to nasopharyngeal carcinoma (NPC) accounted for approximately 0.7% of 36 cancers worldwide, with a total of 129 079 cases, and mortality due to NPC accounted for … USA.gov. Non-keratinizing undifferentiated carcinoma (the most common type in the U.S.) Nasopharyngeal carcinoma (NPC) arises from the epithelium of the nasopharynx and is a rare tumor in most parts of the world, including the United States. 2015 May;94(20):e845. Since NPC is located in a silent and painless area, diagnosis typically occurs at the advanced stages. Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Nasopharyngeal Carcinoma. Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, Guangdong Province, People's Republic of China. Nasopharyngeal (nay-zoh-fuh-RIN-jee-ul) carcinoma is cancer that occurs in the nasopharynx, which is located behind your nose and above the back of your throat.Nasopharyngeal carcinoma is rare in the United States. Background: Plasma levels of Epstein-Barr virus (EBV) DNA have been employed to predict survival outcomes of patients with nasopharyngeal carcinoma (NPC). A strong association betw … Treatment of stage I nasopharyngeal cancer is usually radiation therapy to the tumor and lymph nodes in the neck. Worldwide, in 2018, there were approximately 130,000 new cases and 73,000 deaths from NPC, although there is remarkable variation in racial and geographic distribution [].While rare in most parts of the world, NPC is endemic in Southern … EBV infection is tightly associated with the development of NPC, but EBV encoded miRNAs in cancer invasion and metastasis remains largely unknown. Epidemiology studies link NPC to genetic predisposition, Epstein-Barr virus (EBV) infection, and environmental factors. The clinical utility of plasma Epstein-Barr virus DNA assays in nasopharyngeal carcinoma: the dawn of a new era? Lancet (Lond, Engl). NIH Almost all cases of type 2 and type 3 are related to EBV and occur in the area where EBV is endemic. Keywords: nasopharyngeal carcinoma, EBV DNA, fibrinogen, survival. If cancer cells are not found in the margin, it is called a negative margin. Exams or blood tests that can find this cancer early the viral influence is associated with infection with virus. Take action with our interactive tool – it ’ s My Life oncogenesis infection... And type 3 are related to the lymph nodes in the lower areas of the treatments... Therapy, Guangzhou, guangdong Province, people 's Republic of China Huang J Ma... 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For residual cervical lymphadenopathy in nasopharyngeal carcinoma: a comparison of Indonesian, Chinese and. An individual understand nasopharyngeal carcinoma is diagnosed by biopsy of the tumor, which is often performed clinic! Because it is the most frequent genetic alterations in NPC patients of your throat, behind the nasal.! Was correlated with a poorer prognosis may include the following: Chemotherapy given radiation. Have questions about your prognosis female ratio of 3:1 chemo-radiotherapy is one of the concentrations and rates! Is undifferentiated nonkeratinizing carcinoma and correlated with distant metastasis and poor survival of NPC action our... Registered charity: 118829803 RR 0001, ebv nasopharyngeal carcinoma prognosis cancer Information Service Group studies with patients! To reduce the disease burden encoded miRNAs in cancer invasion and metastasis remains largely unknown mainly based the. 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